Central nervous system (CNS) disease is a broad category of conditions in which the brain does not function as it should. What they have in common is the loss of sufficient, intact nervous system circuits that coordinate a variety of functions, such as memory formation (in Alzheimer’s) and autonomous movement (in dyskinesia). Although most conditions in this group cannot be completely cured, symptoms of CNS disorders can often be managed through a range of treatments, from medical to surgical therapy. Disease models inform our understanding of the pathogenesis of CNS disorder and enable testing of novel therapeutics. Creative Bioarray, a preclinical contract research organization, offers a suite of animal models of neurological disease that are highly predictive, proprietary, slowly developing and environmentally based.

Alzheimer's Disease Models

Alzheimer's disease (AD) is a brain disease that impairs memory, thinking and behavior. At present, the disorder is incurable, thereby increasing the urgency to develop and characterize relevant animal models to facilitate translational research and preclinical drug development. In response to this necessity, Creative Bioarray has developed a variety of experimental models that replicate the pathology of human AD, providing a useful tool for therapeutic screening.

  • Tg2576 mouse model
  • GFAP-Tau mouse model
  • APP/Tau double transgenic mouse model
  • Scopolamine-induced amnesia model

Parkinson's Disease Models

Parkinson's disease (PD) is a neurodegenerative disease characterized by the profound and specific loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Animal models are a key part of preclinical research in Parkinson’s drug discovery. Chemically-induced models are most often rats administered chemicals toxic to dopaminergic neurons. Genetic models focus on mutating or knocking out genes known to cause familial PD. These models do reproduce the key features of PD.

  • 6-OHDA-induced neurotoxic model
  • MPTP-induced neurotoxic model
  • AAV-A53T alpha-synuclein model
  • LRRK2 mutation model

Depression Models

Animal models are important tools for studying the etiology and effective therapeutic targets of depression. Although animal models greatly help our understanding of psychiatric disorders, they do have some limitations, such as the inability to observe feelings of sadness, guilt, or suicidal thoughts, which are mainly limited to humans. Currently, the criteria for identifying animal models of depression depend on either of the two principles: actions of known antidepressants and responses to stress.

  • Stress-evoked model
  • 5-hydroxytrytophan-induced behavioral syndrome
  • Reserpine-induced symptoms
  • Olfactory bulbectomy model
  • Dopamine-induced depression model

Amyotrophic Lateral Sclerosis (ALS) Models

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by selective death of motor neurons in the motor cortex, brainstem, and spinal cord. Creative Bioarray has generated and characterized several animal models of ALS to explore molecular mechanisms of motor neuron disorder and to elucidate pathways of motor neuron degeneration that may be the targets of drug discovery.

  • Nmd mouse model
  • Wobbler mouse model
  • SOD1 mutant mouse model
  • C9ORF72 mutant mouse model
  • TDP43 transgenic mouse model

Epilepsy Models

Epilepsy is one of the most common chronic diseases affecting individuals of all ages. A better understanding of the pathogenesis in epilepsy may provide the basis for the development of new antiepileptic therapies. Animal models play a crucial role in further exploring the mechanisms of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways.

  • Chemoconvulsants-induced recurrent seizures
  • Electroshock-induced seizures
  • Single-evoked epileptic afterdischarges model
  • Kindling model
  • Post-traumatic epilepsy (PTE) model
  • Genetically epilepsy-prone rate
  • Audiogenic seizure susceptible DBA/2 mouse model

Highlights of Our Central Nervous System Disease Research

  • Flexibility to adapt to the last minute study changes
  • Open communication allows you to know the status during your study
  • Scientific contribution to the study design
  • Innovative methods to solve problems
  • Extensive analytical protocols involved in molecular biology, histology and proteomics
  • Wide range of behavior, cognitive and motor function tests
  • Willing to verify the new approaches

Contact us for more information on the listed CNS disease models or you would like to customize a model to meet your specific needs.

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