Metabolic disease is a disorder comprising insulin resistance, glucose intolerance, dyslipidemia, hypertension and obesity, in particular abdominal obesity. Metabolic disease is one of the most important challenges facing public health and biomedical research, the prevalence of which is increasing worldwide as a result of changes in diet and lifestyle. People with metabolic disease have a higher risk of developing diabetes and cardiovascular disease.
In vivo models are important resources for studying the physiological mechanisms of metabolic disorders as well as preclinical translation, which may include the assessment of new treatments. In the study of metabolic disease, in vivo models have unique advantages over in vitro models, which are limited to investigation of isolated systems. At Creative Bioarray, animal models for the study of metabolic disease include diet-induced, chemical-induced, diet and chemical induced models as well as genetic models. These models will help to determine the pathophysiological basis of metabolic disorders and how the metabolic disorders increase the risk of other diseases.
Creative Bioarray has the expertise and experience to assist you in assessing the therapeutic potential of your compounds for obesity, diabetes and associated disorders. We provide a range of animal model testing systems to promote your drug candidates from discovery to IND. Disease-associated biomarkers can also be investigated at Creative Bioarray by using chemistry panels, complete blood counts, ELISA's and lipid panels. In addition, our experts have the experience and infrastructure to study the interactions between microbiome and metabolic diseases, adding a novel and important aspect to your drug development research. Contact us today to discuss your objectives and how we can reach them.