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Cell-based assays measure the functional effects of drugs to determine their biological relevance and physiological importance. Creative Bioarray's contract research and development service professionals are expert in designing standardized or customized cell-based assays, as well as measuring the interaction of drugs (including small molecules, biologics, or device interactions) with cultured cells and primary cells.

Cell-based assays are assays using live cells to offer a relevant representation of a real-life model, promoting the development of focused biological progress. This allows tracking dynamic variables such as the number of cells or their behavior. Cell-based assays can be used to evaluate various functional and biochemical effects, including cell proliferation, apoptosis and cell death, enzyme activity, signal transduction, reporter gene activity, antibody and complement dependent cytotoxicity, among others. Because live cells are used, cell-based assays provide a functional readout of compound activity, or produce results that are more biologically relevant or physiological relevant.

Cell-based assays are valuable tools for drug discovery as they deliver physiologically relevant data on drug effects. Cell-based assays are considered to be the most complex of all bioanalytical methods, and choosing the right partner is a critical decision. Creative Bioarray has longstanding experience in cell-based assays, including primary cells, transformed cell lines and transfected reporter-gene cell systems. The expertise of our scientists enables characterization of many different biological activities of your molecules, such as cell growth, cell death, induction of immunologic effector functions, expression of biomarkers, induction or inhibition of signaling events as well as drug internalization. By combining cell-based assays and drug/target binding assays, Creative Bioarray has the capability to provide a comprehensive assessment of the mode of action of your molecules.

Our assay endpoints include but are not limited to:

  • Cell viability
  • Cell proliferation/cytotoxicity
  • Cell death (apoptosis/necrosis)
  • Cell signaling
  • Receptor/ligand binding
  • Receptor activation/internalization
  • Cell adhesion (static and flow dynamic assays)
  • Cell invasion & migration
  • Biomarker expression (intracellular, secretory and surface marker analysis)
  • Immune and cellular phenotyping (multicolor flow cytometry)

Assay highlights

  • A broad choice of cell lines and primary models, covering multiple disease indications, plus customized stable cell lines
  • Standardized assays, can be fine-tuned to client needs
  • Convenient, easy-to-follow and time-saving protocols
  • Fixed endpoint and real-time high-content microscopy assays
  • Standard and customized homogenous plate reader assays (proliferation, apoptosis, etc.)
  • Confocal microscopy and FACS analysis
  • Single and multiplexed RT-qPCR assays
  • Additional protein profiling assays (e.g., cellular pathway mapping, cytokines from cell supernatant)
  • Fully customized workflow and assay formats are available

Fully validated, we generated our own Drug Discovery Cell Lines

Leverage our successful experience in cell-based assay services. Fully validated, we have generated a stable collection of cell lines to accelerate our clients’ novel drug discoveries and biomedical research, including but not limited to

Creative Bioarray invites you to discuss your specific requirements for cell-based assays with our experts.

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