Cell-based assays measure the functional effects of drugs to determine their biological relevance and physiological importance. Creative Bioarray's contract research and development service professionals are expert in designing standardized or customized cell-based assays, as well as measuring the interaction of drugs (including small molecules, biologics, or device interactions) with cultured cells and primary cells.
Cell-based assays are assays using live cells to offer a relevant representation of a real-life model, promoting the development of focused biological progress. This allows tracking dynamic variables such as the number of cells or their behavior. Cell-based assays can be used to evaluate various functional and biochemical effects, including cell proliferation, apoptosis and cell death, enzyme activity, signal transduction, reporter gene activity, antibody and complement dependent cytotoxicity, among others. Because live cells are used, cell-based assays provide a functional readout of compound activity, or produce results that are more biologically relevant or physiological relevant.
Cell-based assays are valuable tools for drug discovery as they deliver physiologically relevant data on drug effects. Cell-based assays are considered to be the most complex of all bioanalytical methods, and choosing the right partner is a critical decision. Creative Bioarray has longstanding experience in cell-based assays, including primary cells, transformed cell lines and transfected reporter-gene cell systems. The expertise of our scientists enables characterization of many different biological activities of your molecules, such as cell growth, cell death, induction of immunologic effector functions, expression of biomarkers, induction or inhibition of signaling events as well as drug internalization. By combining cell-based assays and drug/target binding assays, Creative Bioarray has the capability to provide a comprehensive assessment of the mode of action of your molecules.
Creative Bioarray invites you to discuss your specific requirements for cell-based assays with our experts.