Determination of drug or drug metabolite concentrations in biological samples, particularly in serum or plasma, is fundamental to describe the relationships between administered dose, the route of administration, and the time after administration for achieving the optimal clinical response. Rapid metabolism lowers drug exposure at the therapeutic target. Certain types of drug molecules, such as those containing ester or amide-linked groups are prone to enzymatic hydrolysis by plasma esterases, amidases or proteases. On the other hand, enzymatic activation of some prodrugs that takes place in plasma is critical for their function. Hence, plasma enzymes can significantly alter the bioavailability of the active compounds, and therefore determination of the compound stability in plasma has both pharmacokinetic and clinical significance.
Plasma stability assay is one of our in vitro ADME screening services. Creative Bioarray delivers consistent, high quality data with cost-efficiency that comes from a highly automated approach.
%disappearance of parent compound, Half-life (t1/2) (multiple time-points assay)
Human, rat, mouse, dog and monkey (additional species are available on request)
Time points (0, 60, 120, 240 minutes) for half-life determinations; 0 and 240 minutes for %disappearance of parent compound
Incubation concentration 1µM
Creative Bioarray has an experienced team of experts dedicated to providing customers with the most reliable and highest quality services. For further information on plasma stability assays and to discuss your specific requirements, please contact us.