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Proteins have the most diverse and dynamic role among all macromolecules in the body, providing intracellular and extracellular scaffold support, forming receptors and channels in membranes, catalyzing biochemical reactions, and transporting molecules within the cell.

Protein therapeutics have several advantages over small molecule drugs. First, proteins usually have highly specific and complex functions that cannot be mimicked by simple chemical compounds. Second, there is often less potential for protein therapeutics to interfere with normal biological processes and cause adverse reactions, as the action of proteins is highly specific. Third, since the body naturally produces many proteins that are used as therapeutics, these agents are generally well tolerated and are unlikely to elicit immune responses. Fourth, for diseases caused by gene mutations or deletions, protein therapeutics can provide effective alternative treatments without the need for gene therapy.

At Creative Bioarray, we understand that getting access to the right protein is a major obstacle to successful downstream research applications in the drug discovery process. Over the past 10 years, we have continuously invested and expanded our expert team, technology platform, capabilities and service scope to one of the most advanced research protein service team in the drug discovery industry. Our scientists, with extensive experience in molecular biology, protein expression, protein purification and structural/physicochemical characterization, will advance your project to match your exact needs from gene synthesis to fully characterized purified proteins using state-of-the-art instrumentation. With their wide technical expertise, our scientists can solve various protein expression and purification challenges.

Protein Expression

With expertise that spans diverse host systems, Creative Bioarray produces a wide range of proteins from mg to g quantities for antibodies, recombinant enzymes and other formats.

  • Expression in bacteria

a) Bacterial hosts such as E. coli, Bacillus

b) Expression screening in E. coli to identify suitable host strain and optimal conditions for expression

  • Expression in yeast

a) Hosts such as Saccharomyces sp. and Pichia pastoris

b) Expression screening to identify suitable host strain and optimal conditions for expression

  • Expression in insect cells

a) Insect Cell Lines used: Sf9, Sf21, High Five

b) Generation of high titer recombinant baculovirus

c) MOI studies

  • Expression in mammalian cells

a) Mammalian Cell lines: CHO-K1, HEK 293, CHO-S, CHO-DG44 etc.

b) Transient transfection for expression and purification of proteins

c) Generation of stable cell lines expressing recombinant proteins

Protein Purification

Our protein scientists work closely with cell biology and in vivo teams to provide tightly integrated solutions for customer development needs. Our expertise lies in the purification of secreted monoclonal antibodies, intracellular tagged proteins, novel cytokine fusion molecules as well as large, complex proteins produced by a variety of expression platforms.

  • Full suite of chromatographic purification techniques
  • Analytical-data-driven purification
  • Various strategies such as refolding, co-purification

Protein Analysis

Creative Bioarray customizes analysis services by focusing on product quality attributes that affect the function of the proteins. We help clients determine functional attributes through industry-leading developability assessments to identify liabilities that may affect preclinical processes and timelines.

  • Protein activity
  • Protein titer/concentration
  • Protein integrity & structure
  • Protein mass
  • Protein stability

Creative Bioarray can help you advance your project, contact us now to discuss further with our accessible and specialized team.

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