Contact Us

USA

Tel:
Fax:
Email:
Europe
Tel:
Email:

Metabolicdiseaseisadisordercomprisinginsulinresistance,glucoseintolerance,dyslipidemia,hypertensionandobesity,inparticularabdominalobesity.Metabolicdiseaseisoneofthemostimportantchallengesfacingpublichealthandbiomedicalresearch,theprevalenceofwhichisincreasingworldwideasaresultofchangesindietandlifestyle.Peoplewithmetabolicdiseasehaveahigherriskofdevelopingdiabetesandcardiovasculardisease.

Invivomodelsareimportantresourcesforstudyingthephysiologicalmechanismsofmetabolicdisordersaswellaspreclinicaltranslation,whichmayincludetheassessmentofnewtreatments.Inthestudyofmetabolicdisease,invivomodelshaveuniqueadvantagesoverinvitromodels,whicharelimitedtoinvestigationofisolatedsystems.

CreativeBioarrayprovidesanumberofrodentmodelsintheareasofdiabetes,obesity,dyslipidemiaandNASH.Thesemodelswillhelptodeterminethepathophysiologicalbasisofmetabolicdisordersandhowthemetabolicdisordersincreasetheriskofotherdiseases.

Diabetes

  • Alloxan-inducedtypeIdiabetes-singleinjectionofalloxan
  • STZ-inducedtypeIdiabetes-singleinjectionofstreptozotocin(STZ)
  • HFD/STZ-inducedtypeIIdiabetes-highfatdiet(HFD)andsingleinjectionofSTZ
  • ob/obmouse
  • db/dbmouse
  • Zuckerdiabeticfatty(ZDF)rat
  • Obesity

  • Diet-inducedobesity(DIO)
  • Zuckerfattyrat
  • Dyslipidemia

  • Cornoil-induceddyslipidemia
  • Intralipid-induceddyslipidemia
  • Non-AlcoholicSteatohepatitis(NASH)

  • STZ-inducedNASH
  • HFD/STZ-inducedNASH
  • AssaysandEndpoints

    AtCreativeBioarray,weconductmetabolicresearchincludingthefollowingassessments:

  • Foodandwaterconsumption
  • Bodyweight
  • Bloodglucose
  • C-peptide
  • HemoglobinA1c(HbA1c)
  • Insulinlevel
  • Cytokinelevel
  • Glucosetolerancetest(GTT)
  • Insulintolerancetest(ITT)
  • Biomarkeranalysis
  • Histopathologyanalysis
  • CreativeBioarrayhastheexpertiseandexperiencetoassistyouinassessingthetherapeuticpotentialofyourcompoundsforobesity,diabetesandassociateddisorders.WeprovidearangeofanimalmodeltestingsystemstopromoteyourdrugcandidatesfromdiscoverytoIND.Disease-associatedbiomarkerscanalsobeinvestigatedatCreativeBioarraybyusingchemistrypanels,completebloodcounts,ELISA's and lipid panels. In addition, our experts have the experience and infrastructure to study the interactions between microbiome and metabolic diseases, adding a novel and important aspect to your drug development research. Contact us today to discuss your objectives and how we can reach them.


    Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry
    For research use only. Not for any other purpose.
    Copyright © 2024 Creative Bioarray. All rights reserved.