Metabolic disease is a disorder comprising insulin resistance, glucose intolerance, dyslipidemia, hypertension and obesity, in particular abdominal obesity. Metabolic disease is one of the most important challenges facing public health and biomedical research, the prevalence of which is increasing worldwide as a result of changes in diet and lifestyle. People with metabolic disease have a higher risk of developing diabetes and cardiovascular disease.
In vivo models are important resources for studying the physiological mechanisms of metabolic disorders as well as preclinical translation, which may include the assessment of new treatments. In the study of metabolic disease, in vivo models have unique advantages over in vitro models, which are limited to investigation of isolated systems.
Creative Bioarray provides a number of rodent models in the areas of diabetes, obesity, dyslipidemia and NASH. These models will help to determine the pathophysiological basis of metabolic disorders and how the metabolic disorders increase the risk of other diseases.
Diabetes
- Alloxan-induced type I diabetes - single injection of alloxan
- STZ-induced type I diabetes - single injection of streptozotocin (STZ)
- HFD/STZ-induced type II diabetes - high fat diet (HFD) and single injection of STZ
- ob/ob mouse
- db/db mouse
- Zucker diabetic fatty (ZDF) rat
Obesity
- Diet-induced obesity (DIO)
- Zucker fatty rat
Dyslipidemia
- Corn oil-induced dyslipidemia
- Intralipid-induced dyslipidemia
Non-Alcoholic Steatohepatitis (NASH)
- STZ-induced NASH
- HFD/STZ-induced NASH
Assays and Endpoints
At Creative Bioarray, we conduct metabolic research including the following assessments:
- Food and water consumption
- Body weight
- Blood glucose
- C-peptide
- Hemoglobin A1c (HbA1c)
- Insulin level
- Cytokine level
- Glucose tolerance test (GTT)
- Insulin tolerance test (ITT)
- Biomarker analysis
- Histopathology analysis
Creative Bioarray has the expertise and experience to assist you in assessing the therapeutic potential of your compounds for obesity, diabetes and associated disorders. We provide a range of animal model testing systems to promote your drug candidates from discovery to IND. Disease-associated biomarkers can also be investigated at Creative Bioarray by using chemistry panels, complete blood counts, ELISA's and lipid panels. In addition, our experts have the experience and infrastructure to study the interactions between microbiome and metabolic diseases, adding a novel and important aspect to your drug development research. Contact us today to discuss your objectives and how we can reach them.
Our customer service representatives are available 24 hours a day, 7 days a week.
Inquiry
For research use only. Not for any other purpose.
Related Services:
