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Since the late 1980s, antibodies have been used as therapies to treat serious diseases, and demand is soaring to new heights today. However, developing such antibody drugs is by no means easy. The basic requirement is that the antibody binds to its target molecule in an optimal way. At the same time, an antibody drug must fulfil a series of additional criteria. For example, it should not trigger an immune response in the body, it should be efficient to produce using biotechnology, and it should remain stable over a long period of time.

Conventional antibody drug discovery is labor-intensive and slow. Pharmaceutical companies select drug candidates from only a small set of antibodies present in the natural immune system, and have limited information on which candidates are the most promising. In addition, identification and selection of drug targets remain an arduous process because the conventional methods of studying the immune system are not comprehensive.

As a leading contract research organization, Creative Bioarray has extensive experience in the development of optimized therapeutic antibodies. Our unique service portfolio allows us to guide you through your antibody drug discovery journey from target selection to clinical candidate. We have successfully developed antibodies for targets range from cytoplasmic, secreted and membrane-bound proteins to anti-idiotypic antibodies. Our expertise can also be applied to the development of immunoassay reagent antibodies, as well as post hybridoma solutions in protein production, efficacy testing and cell line development.

Immune Library Generation

  • Custom build of antibody libraries from immune repertoires for standard and domain antibodies
  • Integration into our drug discovery platform to deliver antibodies with desired profiles

Antibody Humanization

  • Humanization and de-immunization in CDR regions
  • Implementation of in silico design and display technology approaches for optimal antibody sequences

Antibody Production & Characterization

  • Research-scale IgG and antigen expression and purification to support discovery projects
  • Highly purified, quality assessed and endotoxin free proteins

In Silico Modelling

  • Antibody model construction and binding interaction analysis
  • In silico affinity optimization prediction
  • Mutation assessment for humanization
  • Protein patch analysis for aggregation potential and residue liability analysis

Here at Creative Bioarray, we fully understand that each drug discovery campaign is unique. We provide comprehensive work packages with flexible approaches and optimized workflows to deliver bespoke solutions that work for you. Whether you wish to use our proprietary library, have immune libraries that need to be constructed, or require bespoke antibody formats we will work with you to design your workflow for delivery to your specifications.

Antibody Discovery

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