The capability to design, construct and implement assays that are specific, sensitive, and robust enough to identify and characterize potential new drug molecules is fundamental to drug discovery. Since the first success with structure-based drug design using X-ray crystallography in the 1990s, a wide range of biophysical technologies have matured to become key components of drug discovery platform in pharmaceutical companies and academic laboratories. Biophysical data provides an important complement to data on biochemical and cellular activity, as well as aggregation, solubility and cell permeability, which have traditionally been the basis for hit and lead discovery, prioritization and optimization.
As a CRO, Creative Bioarray provides customers with primary and secondary biophysical screening options to determine residence time, mechanism of action, and kinetics, all of which are crucial for the therapeutic action of a drug. We have dedicated biophysicists who can support your comprehensive drug discovery program with a set of high-end technology platforms that can deliver a complete biophysical assessment of the compounds you are interested in.
Biophysics Profiling Technologies
Our biophysics platform provides techniques that can deliver hit finding methods for fragment-based lead discovery and a full mechanistic, structural, kinetic, and thermodynamic profile for your novel compounds. We are adept at deploying these techniques to inform your research project in an efficient and insightful manner.
- Surface plasmon resonance (SPR)
- Isothermal titration calorimetry (ITC)
- MicroScale thermophoresis (MST)
- Thermal shift assay (TSA)
- Mass spectrometry (MS)
- Nuclear magnetic resonance (NMR)
- X-ray crystallography
- BioLayer interferometry (BLI)
- Temperature related intensity change (TRIC)
The Application of Our Biophysical Techniques
We use our biophysical capabilities from hit finding to lead optimization, including extensive use in our fragment-based lead discovery programs. Our biophysical techniques can also provide a full mechanistic, structural, kinetic, and thermodynamic profile of compounds at all stages of the project.
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