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The spread of infectious diseases involves characteristics of the pathogen, the host and the environment where transmissions take place. The purpose of modeling infectious diseases is to evaluate the pathogen-host-environment interface, and strive to change the interface through intervention to our advantages, be they preventive or therapeutic.

Creative Bioarray offers a series of infection modeling services to identify novel anti-infective agents. In addition to standard infection models, we offer custom models optimized to address client specific needs to test candidates against specific subtypes/strains of pathogens. Creative Bioarray also provide safety, in vitro, and pharmacokinetic studies to support the development of anti-infective agents. We offer unique routes of administration, including intracerebral, intracolonic, intravascular, intraocular, dermal, and intraosseous.

Our infectious disease models include a wide range of viral, bacterial, and fungal pathogens to evaluate host-pathogen interactions.

Viral Pathogens

  • Cytomegalovirus (CMV)
  • Herpes simplex virus
  • Influenza
  • Respiratory syncytial virus (RSV)
  • Rhinovirus
  • Lymphocytic choriomeningitis virus (LCMV)

Bacterial Pathogens

  • Campylobacter jejuni
  • Citrobacter rodentium
  • Escherichia coli
  • Klebsiella pneumoniae
  • Pseudomonas aeruginosa
  • Salmonella enterica
  • Staphylococcus aureus (MSSA and MRSA)
  • Streptococcus pneumoniae

Fungal Pathogens

  • Aspergillus fumigatus
  • Candida albicans
  • Cryptococcus neoformans

Endpoints and Capabilities

  • Survival
  • Health score
  • Inoculation routes, including but not limited to intratracheal, nasal, intravaginal, and intramuscular options
  • Bacterial enumeration in organs
  • Viral load in organs
  • Antigen-specific responses (titering and isotyping)
  • Phagocytosis
  • T helper cell (Th1/Th2) ex vivo analysis
  • Semi-quantitative and quantitative cultures
  • Anaerobic chambers for culture and susceptibility tests
  • Customized minimum inhibitory concentrations (MIC)
  • Species level identification
  • Long-term storage

We regularly develop new animal models, assays and readouts at the request of customers. If you don't see what you need, or have any other questions, please contact us.

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