Ophthalmology Models

Ophthalmic diseases such as cataract, glaucoma, age-related macular degeneration (AMD), presbyopia, dry eye disease (DED), ocular allergy and others may lead to visual impairment and blindness. Development of therapeutic strategies for ophthalmic diseases requires a comprehensive understanding of the etiology, molecular and anatomical pathogenic mechanisms and natural history of the disease. Simulating human diseases in animal models is critical to understanding several ocular diseases and developing novel drugs, drug delivery strategies as well as ophthalmic diagnostic technologies. Creative Bioarray specializes in preclinical ophthalmological studies to examine the efficacy of novel compounds and therapeutic modalities. Our models have been well established and optimized to facilitate the generation of reproducible datasets with meaningful endpoints.

Glaucoma (Ocular Hypertension)

• Laser photocoagulation application to the episcleral vein
• Microbead injection into the anterior chamber
• Hyaluronic acid injection into the anterior chamber
• Episcleral vein obstruction
• Episcleral vein saline injection
• Steroid-induced glaucoma models
• Myoc mutation mouse models
• Cyp1b1 mutation mouse models
• Vav2/Vav3 knockout rat models

Cataract

• Emory mice
• Ihara cataract rats (ICR)
• Senescence accelerated mice (SAM)
• UVA-induced cataract
• Naphthalene cataract
• Selenite-induced cataract
• Hyperbaric oxygen (HBO)-induced cataract
• L-buthionine-(S,R)-sulfoximine (BSO)-induced cataract
• Glutaredoxin 2 (Grx2) knockout mice
• Lens GSH synthesis knockout (LEGSKO) mice

Age-Related Macular Degeneration (AMD)

• Laser-induced choroidal neovascularization (CNV)
• CFH transgenic mouse models
• APOE isoform knockin mice
• Ccl2/ and Cx3cr1/ double knockout mouse models
• Subretinal injection-induced CNV models (lipid hydroperoxide, polyethylene glycol and matrigel)

Dry Eye

• Botulinum-induced dry eye in mice
• Scopolamine-induced dry eye in mice
• Concanavalin A-induced dry eye in rabbits
• Glycopyrrolate-induced dry eye in rabbits
• Benzalkonium chloride-induced dry eye in rabbits
• Atropine-induced dry eye in mice and rabbits

Ophthalmic Study Endpoints and Capabilities

Our team has demonstrated extensive and unique expertise in preclinical ophthalmology studies and is committed to providing a complete range of ophthalmology services.

• Ophthalmic examination
• Intraocular pressure (IOP) measurement
• Corneal sensitivity measurement
• Corneal thickness measurement
• Pupillary response assessment
• Full-field and multifocal electroretinography (ERG)
• Visual evoke potential (VEP)
• Optical coherence tomography (OCT)
• Laser photocoagulation
• Fundus photography
• Fluorescein angiography
• Corneal/fundus scanning imaging
• Gonioscopy
• Slit lamp biomicroscopy
• Tonometry
• Pachymetry
• Comprehensive ocular pathology

With extensive experience in visual research, our scientists can help you choose the right model and experimental design to achieve your research and development goals.

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