Gastrointestinal Disease Models

Animal studies are the gold standard for preclinical and translational studies of gastrointestinal (GI) disease. Although there are now specialized cell lines and "organs-on-a-chip" that provide in vitro platforms that can be used for drug selectivity and specificity studies, only whole-animal physiology can approximate clinical pathology and the effects of novel therapeutics.

Creative Bioarray has extensive experience in GI studies for a variety of indications. Our expertise in GI preclinical research and consistent track record of success as a full-service CRO ensures the flexibility to adapt to the unique needs of each trial. Our disease models are suitable for testing disease-modifying drug or compounds acting on symptomatic effects. Depending on your needs, it is possible to perform classical, oral (PO), intravenous (IV), intraperitoneal (IP) or intrarectal administration.

Irritable Bowel Syndrome (IBS)

• Water avoidance stress (WAS)-induced colonic hypersensitivity
• Restraint stress-induced colonic hypersensitivity
• Brain or spinal cord manipulation-induced colonic hypersensitivity
• Acetic acid or butyrate enema-induced colonic hypersensitivity
• Capsaicin-, mustard oil-, or zymosan-induced inflammatory colonic hypersensitivity
• Post-inflammatory colonic hypersensitivity

Inflammatory Bowel Disease (IBD)

• Dextran sodium sulfate (DSS)-induced colitis
• 2,4,6-Trinitrobenzene sulfonic acid (TNBS)-induced colitis
• Indomethacin-induced intestinal inflammation

Ulcer

• Acetic acid-induced ulcer
• Pylorus ligation ulceration models
• HCl/ethanol-induced ulcer
• Restraint stress/cold-restraint stress-induced ulcer
• Acetylsalicylic acid-induced ulcer
• Indomethacin-induced ulcer
• Piroxicam-induced ulcer

Gastroparesis

• Phenol red/blue dextran/methylene blue meal models
• Solid food emptying models
• [¹³C]-octanoic acid breath test models
• Barium meal models
• Plasma acetaminophen models

Endpoints

We have extensive experience with studies involving the following types of evaluation criteria:

• Disease activity index (DAI)
• Manometric recording
• Number and intensity of abdominal contractions
• Gastric lesions quantification
• Retching, vomiting, nausea-like behavior
• Nausea and emesis events
• Gut motility evaluation
• Percentage of remaining red phenol in the stomach
• Distance covered by charcoal and transit percentage
• Inflammation, myeloperoxidase (MPO) activity, ELISA dosage (cytokines level), histology, etc.

If you don't see the model you need, our skilled team has experience quickly reproducing models from the literature. Contact Creative Bioarray to discuss your specific research needs with our scientific team.

Related Services:

• Inflammatory Disease Models
• Cardiovascular Disease Models
• Respiratory Disease Models
• Oncology Models
• Pain Models
• Neurology Models
• Ophthalmology Models
• Metabolic Disease Models
• Infectious Disease Models
• Dermatology Models
• Renal Disease Models