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Proteases are one of the largest enzyme family encoded by the human genome. By catalyzing the hydrolysis of peptide bonds, an enzymatic reaction contributes to the regulation of proteolysis mechanism that is the core of many physiological and pathological processes, such as cell proliferation, embryonic development, tissue remodeling, protein activation and maturation, protein transport, and protein catabolism.

Proteases play a significant role in a number of signaling pathways and represent potential drug targets for diseases ranging from cardiovascular disorders to cancer, as well as for combating many viruses and parasites. Currently, there are eight approved compounds for the treatment of HIV infections that are in the class known as protease inhibitors. In addition to HIV, protease inhibitors have been approved for treatment of the Hepatitis C, ACE inhibitors, are being studied in relation to Type II diabetes, Alzheimer disease, and other indications.

Creative Bioarray provides access to a fully defined, flexible profiling and screening service for potential drug inhibitors of protease targets in drug discovery. Our flexible services of over 50 proteases spanning across cysteine, metalloproteinases, serine, threonine, aspartic families and other protease targets have been designed to facilitate your drug discovery process.

Protease Screening Services Available

  • Larger scale high throughput screening
  • Large scale single dose and duplicate profiling
  • IC50 profiling - 10 dose with curve fitting
  • Protease substrate determination based on peptide library
  • Custom assay development

Protease Screening Targets

Cysteine ProteasesCaspase-1Caspase-2Caspase-3Caspase-4Caspase-5Caspase-6
Caspase-7Caspase-8Caspase-9Caspase-10Cathepsin BCathepsin H
Cathepsin KCathepsin LCathepsin SCathepsin VCalpainLegumain
NeprilysinNeprilysin 2    
Serine ProteasesThrombinFactor XaDPP3DPP4DPP7DPP8
Proteinase 3Trypsin    
Aspartate ProteasesCathepsin DCathepsin EHIV-1PepsinRenin 

Key Advantages

  • High sensitivity and exceptional reproducibility
  • Small sample requirement - only nanoliters of compound required
  • Perform follow-up studies by using the same proteins manufactured in-house
  • Receive data within days of compound submission
  • Get questions answered or project guidance in a time-efficient manner

Creative Bioarray offers protease compound screening services which can accelerate your drug discovery program. It is our commitment to offer you high-quality data with fast turnaround time. If you have any special requirements in protease screening and profiling, please feel free to contact us. We are looking forward to working together with your attractive projects.

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