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Inhalation of gases and vapors can cause a wide range of adverse health effects, ranging from simple irritation to systemic diseases. The large amounts of chemicals and complex mixtures present in indoor and outdoor air coupled with the introduction of new materials such as nanoparticles and nanofibers have made it an area of increasing concern for human health. Experimental animals have been used to study the toxic effects of chemicals for many years. However, even so, little is known about the potential toxicity of most inhaled chemicals.

Creative Bioarray specialized in inhalation toxicology testing. We integrate cutting-edge expertise in exposure technology, generation and characterization of exposure atmospheres, dosimetry, and evaluation of health outcomes as needed to quickly meet study goals. Creative Bioarray’s inhalation toxicology facility has the ability to perform single or repeated, nose-only or whole-body inhalation exposures on all laboratory species. In addition, we have extensive experience in aerosol toxicity testing to determine lethal doses and exposure limits through acute, chronic and subchronic inhalation toxicity studies.

Inhalation Toxicity Services

  • Acute Inhalation Toxicity (LC50) - OECD TG 403
  • Subacute Inhalation Toxicity - OECD TG 412
  • Subchronic Inhalation Toxicity - OECD TG 413
  • Acute Inhalation Toxicity (Toxic class) - OECD TG 436

Test Compounds

  • Pharmaceuticals (small molecules, recombinant proteins, cell and gene therapies, bacteriophages)
  • Nanoparticles and novel formulations
  • Potential airborne pollutants
  • Poorly soluble particles
  • Airborne consumer products
  • Electronic cigarettes or tobacco product

Inhalation Delivery Systems

  • Nose-only or whole-body inhalation exposure (rodents)
  • Oronasal inhalation exposure (large animals)
  • API-sparing dry powder or liquid intratracheal administration
  • Intranasal administration

We offer a comprehensive set of standard inhalation toxicology studies, as well as custom solutions to address unique problems. Our experts can design, test and characterize novel inhalation delivery systems, develop new methods of aerosolizing compounds, and determine precise dosing concentrations based on your study requirements.

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