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Kidney disease is a devastating illness with high morbidity and mortality. The incidence of end-stage renal failure is increasing at a rate of 6-8% annually worldwide. Animal models are essential for understanding the pathogenesis that governs the onset and progression of various kidney diseases, as well as for preclinically testing of novel and more effective treatments for patients afflicted with renal impairment. Creative Bioarray provides a wide range of animal paradigms that simulate human conditions of acute kidney injury (AKI) and chronic kidney disease (CKD), including acute renal failure, acute and chronic renal ischemia/reperfusion, nephrotoxicity, and diabetic nephropathy.

Acute Kidney Injury & Failure (AKI/ARF)

  • Unilateral ureter occlusion (UUO) models
  • Renal ischemia/reperfusion (I/R) models
  • Cecal ligation and puncture (CLP) models
  • Glycerol-induced rhabdomyolysis models

Chronic Kidney Disease (CKD)

  • 5/6 NPX + NaCl (pole ablation method) models
  • 5/6 NPX (renal infarction method) models
  • Angiotensin II infusion models

Diabetic Nephropathy (DN)

  • Streptozotocin (STZ)-induced mouse/rat models
  • Akita mouse
  • NOD mouse
  • ob/ob mouse
  • db/db mouse
  • Zucker diabetic rat
  • BTBR mouse
  • OVE26 (FVB) mouse

Glomerular Nephropathy

  • Nephrotoxic serum nephritis (Anti-GBM Ab) models
  • Passive Heymann nephritis (Anti-Fx1A Ab) models
  • Thy-1 nephritis models
  • Puromycin-induced podocyte injury models
  • Cisplatin-induced nephrotoxicity models

If you don't see the model you need, our skilled team has experience to quickly reproduce models from the literature. Contact Creative Bioarray to discuss your specific research needs with our scientific team.

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