Pain Models

Pain is a complex multidimensional experience involving the dynamic interaction between sensory-discriminative and affective-emotional processes. Despite the tremendous progress in understanding its basic mechanisms, pain is still a significant health problem.

Pain experiments using human subjects are actually challenging, fundamentally subjective, and ethically self limiting, and thus laboratory animal models of pain are widely used. Animal models of pain date back to the late 19th century and play a vital role in our understanding of the pain process. Since then, a large number of animal models have been developed to better understand pain from various disease states, both acute and chronic, and have proven useful in further advancing disease-specific questions and processes.

At Creative Bioarray, we have several animal models that can be used to study pain. These models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which address pain therapeutic endpoints and pain-associated symptoms and side effects.

Acute Pain

• Hot plate
• Tail flick
• Capsaicin
• Acetic acid writhing
• Pin-prick

Neuropathic Pain

• Spinal nerve ligation (SNL)
• Chronic constriction injury (CCI)
• Spared nerve injury (SNI)
• Streptozotozin (STZ)-induced neuropathic pain
• Chemotherapy-induced neuropathic pain (vincristine, cisplatin, oxaliplatin)

Inflammatory Pain

• Carrageenan-induced inflammatory pain
• Complete Freund’s Adjuvant (CFA)-induced inflammatory pain
• Mono-iodoacetate (MIA)-induced inflammatory pain
• Ultraviolet irradiation-induced inflammatory pain

Post-Operative Pain

• Brennan models

Visceral Pain

• Colorectal distention
• Urinary bladder sensitivity

Endpoints

Our study design provides a robust data package that you can be confident in using to make key decisions in your development strategy.

• Body weight
• Thermal hyperalgesia
• Mechanical allodynia
• Paw edema
• Joint compression
• Behavioral observation
• Composite behavior score
• Biomarkers
• Histology

Related Services:

• Inflammatory Disease Models
• Cardiovascular Disease Models
• Respiratory Disease Models
• Oncology Models
• Neurology Models
• Gastrointestinal Disease Models
• Ophthalmology Models
• Metabolic Disease Models
• Infectious Disease Models
• Dermatology Models
• Renal Disease Models