Evaluating the potential side effects of human pharmaceuticals on the immune system should be incorporated into standard drug development process. Toxicity to the immune system includes inhibition or enhancement of the immune response. Inhibiting the immune response can result in a decrease in host resistance to infectious agents or tumor cells, while enhanced immune response can exacerbate autoimmune diseases or allergies. Currently, the assessment of immunotoxic effects depends on different animal models. With a few exceptions, the immune system of humans and experimental animals are very similar. Most drugs that inhibit the immune system in humans produce similar results in rodents, and the mechanisms for immunosuppressive action are similar.
Creative Bioarray has validated and implemented a series of standardized immunotoxicity testing protocols based on experimental animal models, which are fully compliant with international guidelines and recommendations. These methods are described below:
Preclinical immunotoxicology studies can help identify negative effects or unpredictable behaviors so they can be corrected and prevented. At Creative Bioarray, our in-house processes are designed to guarantee maximum efficiency and to ensure you receive high-quality reports within a competitive timeframe. Please feel free to contact us, if you have any needs.
