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Systemic administration of drugs can cause several common and distinct ophthalmic adverse reactions that may be related to the pharmacodynamic or pharmacokinetic action of a drug and possibly even serve as a marker of toxicity.

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Anatomical and physiological differences between species can affect the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular toxicity in experimental animals provides a concise reference for ocular anatomy and physiology of different species, which will contribute to the design and interpretation of toxicological studies.

Creative Bioarray is proficient in ocular toxicology research and can support any phase of your preclinical development program with in vivo studies and complete histopathological evaluation for your therapeutics. We have specialized techniques including ERG, OCT, pachymetry, tonometry and fundus angiography for toxicology and pharmacology assessments.

Ocular Toxicology Services

  • Lacrimation assessment
  • Pupillary diameter testing
  • Ocular irritation, tolerability and sensitization studies
  • Contact lens toxicity
  • Ocular implant toxicity
  • Punctal plug toxicity
  • Single-dose ocular toxicity
  • Multiple-dose subacute and chronic ocular toxicity

Routes of Administration

  • Intravitreal
  • Periocular
  • Subretinal
  • Retrobulbar
  • Intrastromal
  • Lacrimal glands
  • Anterior and posterior chamber
  • Conjunctival or subconjunctival

Ocular side effects induced by systemic drugs are increasing due to the introduction of a large number of new drugs. Reports of drug-induced ocular toxicity must be well documented and other causes of these side effects must be ruled out to help determine causality. At Creative Bioarray, all tests are performed by qualified ophthalmologists, who work closely with experienced pathologists to ensure a complete interpretation of the results. Contact us today to learn more!

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