As the largest organ in the human body, skin plays a vital role in overall health and well-being. Creative Bioarray has extensive experience providing an arsenal of innovative and validated pharmacological models for dermatological research, covering FITC/DNCB-induced dermatitis, imiquimod/IL23-induced psoriasis, oxazolone-induced delayed-type hypersensitivity as well as passive cutaneous anaphylaxis. These models are supported by a range of readouts including protein, mRNA, histology and flow cytometry. Whether you're looking for wound healing, acne models, psoriasis, or more complex dermal inflammation models, Creative Bioarray can meet your needs. Our capabilities range from assisting in investigative drug discovery to pharmacokinetics and toxicological studies.
Dermal Wound Healing
Wound healing is a complex multifaceted biological process involving local and systemic factors in multiple tissue types. A successful experimental model will encapsulate each phase to better understand the mechanisms of wound repair and the development of biological therapeutics. The in vivo model has the advantages of simulating wound repair that is most similar to clinical cases. For example, the host’s vascular and immune systems as well as the external environment, can affect animal models like humans. Creative Bioarray offers various models of wound healing in both rodents and pigs.
- Full and partial thickness incisional wounds
- Excisional wounds
- Heat wounds
- Pressure wounds
- UV wounds
- Burn wounds
- Surgical wounds
Atopic Dermatitis
Atopic dermatitis (AD) is a chronic or chronically relapsing, pruritic inflammatory skin disease. Many AD patients have a family history of asthma, allergic rhinitis, and a tendency to overexpress IgE. AD is considered to be a persistent antigen-specific dermatitis with a Th2 cytokine profile. Creative Bioarray has developed a variety of models, each of which is suitable for the study of AD at different stages and types.
- Nc/Nga spontaneous mice
- Oxazolone-induced mice
- Ovalbumin-induced mice
- 2,4,6-trinitrochlorobenzene (TNCB)-induced mice
- IL-31 transgenic mice
- TSLP transgenic mice
- Caspase-1 and IL-18 transgenic mice
- Cathepsin E. knockout mice
- Passive cutaneous anaphylaxis mice
Delayed-Type Hypersensitivity
The delayed-type hypersensitivity (DTH) reaction is a typical in vivo assay to study cell-mediated host immune function. In preclinical studies, DTH models are widely used for the evaluation of novel immunosuppressive and immunomodulatory agents, as well as for vaccine development. Creative Bioarray has validated study models to be able to test compounds that target DTH in the skin resulting from either injection or absorption of the antigen.
- Oxazolone-induced DTH models
- Tetanus toxoid (TTx)-induced DTH models
- Keyhole limpet hemocyanin (KLH)-induced DTH models
Psoriasis
Psoriasis is an incurable inflammatory, chronic, systemic and genetic skin disorder with a prevalence of 2-3% worldwide. The specific pathogenesis of psoriasis is not fully understood, but the underlying mechanisms involve complex interactions between epidermal keratinocytes, T lymphocytes as well as other leukocytes and vascular endothelium. Animal models are very popular for the study of psoriasis. Creative Bioarray’s preclinical psoriasis models help to replicate psoriasis by topical application of imiquimod (IMQ) on the skin of a nude mice. Imiquimod-induced psoriasis is highly correlated with human psoriasis and is widely accepted as a reliable preclinical psoriasis model. In addition, we also provide spontaneous mutant models and genetically engineered models.
- Imiquimod (IMQ) topical application mouse models
- IL23 intra-dermal application mouse models
- Flaky skin mouse spontaneous models
- Chronic proliferative dermatitis mouse spontaneous models
- CD18 hypomorphic mouse transgenic models
- p40 keratin 14 (K14) transgenic mice
- αE integrin (CD103) knockout mice
- HLA-B27/human β2 microglobulin transgenic rats
Acne
Acne is a common disorder with a variety of physiological symptoms including comedones, papules, pustules, nodules, cysts and pilosebaceous inflammation, which are rarely life-threatening, but great attention should be paid to the psychological morbidity. Creative Bioarray has many in vivo models related to acne, which can be used to assess the pharmacological efficacy of your compounds at your disposal.
- Rhino mouse models
- P. acnes infection mouse models
- Rabbit models
Are you looking for a new model or one not listed above? We would be happy to work with your team to validate and pilot a new model. Contact our scientist today to discuss your needs.
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