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Cytokines are a broad class of soluble proteins, glycoproteins, and peptides that act as chemical messengers of the immune system. These small proteins are important intercellular communicators, carrying messages from one cell to another and contributing to cell growth and immune response.

Cytokines include chemokines, interferons, interleukins, lymphokines and cannot cross the lipid bilayer of the cell wall to enter the cytoplasm. They have been shown to be key players in endocrine, autocrine and paracrine signaling as immunomodulators.

Cytokines play a major role in immune responses, inflammation, wound healing and hematopoiesis. They are involved in the physiopathology of autoimmune disorders, as well as infectious, allergic and cancerous diseases. Cytokine measurement can support many therapeutics discovery programs including cardiovascular, inflammation, immunology, oncology, metabolic syndrome and CNS disorders. The cytokine analysis can be used as an indicator of drug efficacy, but also as a companion diagnostic to support clinical studies.

Cytokine Analysis Services at Creative Bioarray

Creative Bioarray is an innovative Contract Research Organization dedicated to providing accurate and reproducible biomarker analysis services.

We are pleased to offer ELISA and Multiplex analysis of many cytokines including: BMPs, EGF, FGF, G-CSF, GM-CSF, IFN-gamma, IGF, IGF-BPs, IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IP-10, Leptin, MCP-1, M-CSF, MIG, MIP-1a, beta-NGF, PDGF, SCF, TNF-alpha, TPO, TRAIL and VEGF. The cytokine analysis services can be also customized upon to your requirements in your drug development.

Methods Available for Assessment of Cytokines

  • Cytokines in cellular supernatants:

a) Bioassays and immunoassays for cytokine levels
b) Bioassays and immunoassays for cytokine soluble receptor levels

  • Cytokine production by populations of cells:

a) Multiparameter flow cytometry for cytokine positive cells
b) Magnetic beads-based quantification or isolation of cells secreting cytokines
c) Transcripts for cytokines or cytokine receptors (ISH, RT-PCR, Northern blot, RNase protection assay)

  • Single-cell assays for cytokine expression or secretion:

a) Intracytoplasmic cytokine staining (ICc)
c) mRNA-based assays

  • Detection of cytokines in tissues:

a) Immunocytochemistry
b) Immunofluorescence
c) mRNA-based assays

Our veteran team possesses expertise in primary cells and transformed cell lines, and is a clear choice for cell-based assay and immunoassay development and analysis. Contact us today for more information on our wide range of bioanalysis services.

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