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Analytical chemistry is an important tool for process chemistry, medicinal chemistry and pharmacological studies. Creative Bioarray has a team of highly skilled analytical chemistry experts who can perform challenging specific tasks and assist organic chemists and pharmacologists during their studies.

Our experienced team offers you access to a unique analytical/bioanalytical method development resource, and by solving any problems encountered along the way, they provide you with robust data to drive forward your chemical or biological projects. In addition to stand-alone solutions, our analytical team can be deployed as part of our integrated services along with our synthetic, medicinal and computational chemistry, X-ray crystallography, ADME/bioanalytical and bioassay teams.

We provide state-of-the-art instruments and expertise to identify, purify, characterize and quantify many different classes of chemical compounds from the most diverse matrices. Our staff can offer three major areas of expertise:

  • Drug metabolism and pharmacokinetics activities required for the progression of drug discovery projects
  • Advanced structural elucidation of the chemical compounds
  • Proteomics and metabolomics studies aiming at elucidating the molecular mechanism underlying pathophysiological states and identifying disease biomarkers

Application

Creative Bioarray's mass spectrometry-based analytical services can be used at various stages of the drug discovery process:

  • Biomarker discovery: lipidomics, proteomics, and targeted disease pathway studies
  • Drug property screening: high-throughput solubility, log D, and aqueous stability studies
  • Analytical support for:
  • dosing, formulation, and drug release
    drug metabolism (e.g., liver microsome stability and metabolic fate studies)

  • Pharmacokinetics (PK): method development and analysis of drugs from high-throughput PK screening of early-phase drug candidates or plasma and tissue drug distribution and clearance studies

Highlights

  • Dedicated team of trained analytical chemists
  • Close interaction with the project teams
  • Flexible to meet project needs
  • Fast turnaround time
  • Reproducible high-quality data

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