Aging is an inevitable process for all living organisms. In humans, the skin is the most markedly affected tissue.
Skin aging is a complex phenomenon that causes numerous changes to the skin components and is accompanied by various symptoms such as dryness, wrinkles, pigmentation, darkening, decreased dermal thickness and a loss of elasticity. Due to the gradual aging of various populations worldwide, and the advancement of science associated with aging, a variety of anti-aging procedures have been developed, such as cosmetics, photoprotection, and antioxidants, to prevent and treat skin aging. The business of anti-aging cosmetics, including cosmeceuticals, is growing rapidly in the skincare market and may have potential benefits for the care of elasticity, wrinkles, skin tone, and dermal density. However, although clinical experience suggests an important role for topical anti-aging formulations, such as eye cream and anti-wrinkle cream, further empirical studies are still needed to investigate their underlying mechanisms and confirm their effects.
Increasing ethical attention to animal experiments have led to the development of various alternative methods based on the 3Rs (Refinement, Reduction and Replacement). Cosmetic research and skin ageing research are particularly susceptible to concerns related to animal testing. In addition to animal welfare reasons, there are scientific and economic reasons to reduce and avoid animal experiments. Importantly, animal experiments may not reflect the findings in humans, mainly because of the differences in architectures and immune responses between animal skin and human skin.
Biochemical methods are useful for direct analysis of the key reactions of skin ageing. For example, some enzymes are closely related to skin ageing. The activity of elastase, which can break down elastin fibers, provides an indication of dermal connective tissue damage, leading to wrinkles and sagging skin. Collagenase breaks down collagen, and thus, inhibiting collagenase may be an effective way to prevent wrinkles. These enzymes can be determined chemically and directly.
At Creative Bioarray, we don't want to set limits to your drive for research! From classic efficacy studies to the demonstration of innovative parameters, we are happy to assist you with a variety of methods in efficacy testing.
We can evaluate the anti-ageing effect of active cosmetic compounds on:
- cell renewal (cell proliferation, differentiation and migration)
- extracellular matrix synthesis and degradation (collagen, elastin, hyaluronic acid, MMPs, etc.)
- senescence marker expression
- free radical production
Creative Bioarray has many in vitro models at your disposal:
- Fibroblasts
- Keratinocytes
- Three-dimensional (3D) reconstructed human skin equivalents
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