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The preference for white skin has driven the skin lightening industry. Skin whitening products that propose to lighten the skin's appearance or treat hyper-pigmentation have become highly desirable in the cosmeceutical industry. The use of skin whitening cosmetics has an important role in achieving skin whitening and diminishing dark spots on the skin.

Melanin is the major pigment contributing to human skin color. Melanin is produced and distributed by melanocytes, which are specialized skin cells found in the basal layer of the epidermis. The melanin is distributed to keratinocytes, and keratinocytes proliferate and move toward the skin surface, giving the skin a characteristic color. Melanin is synthesized from tyrosine in melanosomes, which are vesicles in melanocytes. The synthesis of melanin is also known as melanogenesis. This process is catalyzed by different enzymes, the key ones are tyrosinase (TYR), tyrosinase-related protein (TYRP1) and dopachrome tautomerase (DCT).

Hyperpigmentation is the result of altered melanin production, which leads to uneven skin pigmentation. It can be triggered by different factors, mainly sun exposure (UV light, which causes dark spots, also known as sunspots), hormones (melasma), age (sun or age spots) and inflammation (post-inflammatory pigmentation, such as acne damage).

Creative Bioarray is a company focuses on in-depth technology of health and beauty, and has extensive expertise in this field. We believe in strong collaboration and in bringing in all expertise together to provide our customers with excellent service.

Creative Bioarray has many in vitro or ex vivo models for your disposal:

  • Melanocytes (B16, etc.)
  • Normal human epidermal melanocytes (NHEM)
  • Co-culture of normal human epidermal melanocytes and keratinocytes (NHEM/ NHEK)
  • Reconstructed epidermis containing melanocytes
  • Skin explants (ex vivo)
  • Hair follicle (ex vivo)

On which we can evaluate the whitening or pro-pigmenting effect of active cosmetic compounds or formulations by measuring:

  • Tyrosinase activity and expression
  • Melanin synthesis
  • The expression of specific markers of melanogenesis: TYR, TRP-1, Pmel17, MITF, etc.
  • Melanocyte dendricity
  • Melanosome transfer

We serve a wide range of companies in pharmaceutical and cosmeceutical markets, such as:

  • Cosmetic brand owners
  • Cosmetic private label manufacturers
  • Cosmetic safety testing agencies
  • Entrepreneurs in health and beauty industry
  • Cosmetic natural active ingredient extract suppliers
  • Pharmaceutical natural active ingredient extract suppliers
  • Pharmaceutical products manufacturers

We are very happy to provide you with consultation services regarding Whitening/Lightening/Brightening performance testing and other efficacy testing services that you are interested in.


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