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Cell-derived xenograft (CDX) model is a well-recognized and commonly used model for research and development of anti-tumor drugs. The CDX model is also widely used in the early stage of in vivo study due to its user-friendly technology and excellent repeatability.

CDX model is established by inoculating long-term, in vitro passaged tumor cells into immunodeficient mice. As an indispensable step in the discovery process of tumor drugs, CDX model offers key decision-making information to allow agents to move forward, and clients to advance their preclinical development programs in a timely and cost-effective manner.

Cell-based Xenograft Models

Creative Bioarray has a list of more than 90 tumor cell lines that can be used in immunocompromised mice. Stocks of tumor cells are well defined and obtained only from trusted sources. We can also provide subcutaneous, orthotopic, or metastatic tumor models according to the customer's requirements, as well as in vivo pharmacological and pharmacodynamic services for the corresponding models.

Standard in vivo models are available for the following cell lines:

Tumor TypeCell Line
Brain cancerLN229, SF268, SF295, SF539, SK-N-AS, SNB-19, SNB-75, U-251 MG, U87 MG
Breast cancerBT474, BT-549, HS578T, KPL-4, MCF-7, MDA-MB-157, MDA-MB-231, MDA-MB-453, MDA-MB-468, T47D
Colon cancerCOLO-205, CT-26, DLD-1, HCT116, HCT-15, HT-29, KM-12, L0Vo, LS-174T, MC38, RKO, SW480, SW-620, WiDr
Gastric cancerAGS, HS746T, MKN-45, NCI-N87, SNU-16, SGC-7901
Hepatocellular cancerHepa1-6, Hep3B, HepG2, SK-HEP-1, SMMC-7721
Kidney cancer786-O, A498, Caki-1, HEK-293, Renca
Leukemia/LymphomaA20, DOHH2, EL-4, HL-60, K-562, Karpas-299, MOLM-13, Ramos, Raji
Lung cancerA549, Calu-3, Calu-6, H1155, Huh7, NCI-H226, NCI-H460, NCI-H1975
MelanomaA375, A2058, SK-MEL-2
Ovarian cancerOV-CAR3, SKOV-3
Pancreatic cancerAsPC-1, BxPc-3, MIAPaCa-2, PANC-1
Prostate cancerDU-145, LNCaP, MDA-PCA2b, PC-3
OthersFaDu, HeLa

Creative Bioarray also provides a complete set of laboratory services, including:

  • Xenotransplantation study design
  • Selection of appropriate cancer model/cell line
  • Host animal selection
  • Subcutaneous or orthotopic xenografting
  • Daily observation of experimental subjects
  • Post-experiment analysis

Choose one of our available mouse xenografts, or contact us to establish xenograft model for your specific in vivo efficacy studies.

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