Skin corrosion refers to the production of irreversible damage to the skin manifested as visible necrosis through the epidermis and into the dermis, following the application of a test chemical. The potential for chemical-induced skin corrosion is an important consideration in establishing procedures for the safe handling, packing, and transport of chemicals.
The in vitro skin corrosion test has been validated as alternatives to animal use for skin corrosion test, thus avoiding pain and suffering of animals. This test addresses the human health endpoint skin corrosion.
In vitro skin corrosion test complements our existing skin toxicology service portfolio of in vitro skin irritation and in vitro skin sensitization tests, enables chemical risk assessments to be performed. Our proficiency exercise generated the correct prediction of corrosive potential and the correct assignment of chemicals into corrosive subcategories.
If you are confused about how to perform skin corrosion testing on your substance, whether for hazard identification/labelling in compliance with regulatory or within the development process of new products, Creative Bioarray is here to help you develop your strategy.
How to choose the right skin corrosion test for your needs
- Reconstructed human epidermis (RHE)
- Membrane barrier
- Transcutaneous electrical resistance (TER)
The following table shows the predictive capacity of the three in vitro skin corrosion tests vs the Draize test.
| | Sensitivity | Specificity | Accuracy |
| TG431: RHE | >95% | >90% | >82.5% |
|---|
| TG435: Memb. Barrier | 86% | 68% | 81% |
|---|
| TG430: TER | 88.1% | 72.4% | 79.4% |
|---|
| TG404: Draize | N/A (reference) | N/A (reference) | N/A (reference) |
|---|
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