CHO-K1-DP2/Gα15-Stable Cell Line
| Catalog Number |
CBCL-0159 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
The CHO-K1-DP2/Gα15-Stable Cell Line is engineered to stably express the DP2 (prostaglandin D receptor 2) and the Gα15 protein.
Application
Drug screening and biological assays
Background
PTGDR2, also known as CRTh2 or DP2, is a G-protein coupled receptor that binds PGD2 and other prostaglandin-like molecules. It is primarily expressed on immune cells such as Th2 cells, eosinophils, and basophils. Activation of PTGDR2 by PGD2 leads to the recruitment and activation of these immune cells, contributing to the pathogenesis of allergic diseases such as asthma and atopic dermatitis. PTGDR2 antagonists are being developed as potential treatments for these conditions.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
CHO-K1-DP2/Gα15-Stable Cell Line |
| Protein Family |
Prostanoid receptor |
| Gene |
PTGDR2/DP2 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F12, 10% FBS, 100 μg/ml Hygromycin B, 3 μg/ml puromycin |
| Freeze Medium |
45% culture medium + 45% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
