CHO-K1-GPR103/Gα15-Stable Cell Line
| Catalog Number |
CBCL-0150 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
Recombinant CHO-K1 cells have been developed to stably overexpress human pyroglutamylated RFamide peptide receptor (QRFPR) on their surface. These cells contain high levels of the G protein Gαq, which is essential for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
QRFP/GPR103 is a G-protein coupled receptor that binds the neuropeptide QRFP (also known as 26RFa). QRFP is involved in the regulation of appetite, energy balance, and body weight. It acts on GPR103 in the hypothalamus to modulate food intake and energy expenditure, making it a potential target for the treatment of obesity and related metabolic disorders.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
CHO-K1-GPR103/Gα15-Stable Cell Line |
| Protein Family |
Peptide P518 receptor |
| Gene |
QRFP/GPR103 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 400 μg/ml Geneticin, 100 μg/ml Hygromycin B |
| Freeze Medium |
45% culture medium + 45% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
