HEK293-ADORA1/Gα15-Stable Cell Line

Introduction

Recombinant HEK293 cells have been developed to stably overexpress human adenosine A1 receptor (ADORA1) on their surface. These cells contain high levels of the G protein Gαi, which is crucial for coupling with the receptor in downstream signaling pathways.

Application

Drug screening and biological assays

Background

The ADORA1 - encoded adenosine A1 receptor is a key component in the adenosine - mediated signaling pathways. In the brain, it helps to fine - tune neuronal activity by inhibiting the release of excitatory neurotransmitters like glutamate. In the heart, activation of A1 receptors can slow down the electrical conduction and reduce the force of contraction, which can be beneficial in certain cardiac arrhythmias. In adipose tissue, it suppresses the breakdown of triglycerides into free fatty acids, thus affecting energy metabolism.

Product Information