HEK293-CFTR-Recombinant Cell Line

Introduction

The CFTR HEK293 Cell Line expresses full-length, wild-type human cystic fibrosis transmembrane conductance regulator (CFTR) protein (Genbank #P13569, NP_000483.3), featuring a C-terminal Streptavidin-Binding Peptide (SBP) tag.

Application

Drug screening and biological assays

Background

Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel protein that regulates the movement of chloride ions across cell membranes. Mutations in the CFTR gene cause cystic fibrosis, a genetic disorder characterized by thick, sticky mucus in the lungs, pancreas, and other organs, leading to chronic respiratory infections, digestive problems, and other complications. CFTR is expressed in various epithelial cells and plays a critical role in maintaining fluid balance and electrolyte transport.

Product Information