Introduction
An engineered HEK293 cell line that stably expresses full-length human Transferrin Receptor Protein-1 (TFRC and TFR1, also known as human CD71 protein, GenBank accession #NM_001128148), a cell surface receptor involved in iron homeostasis. Dysregulation of iron homeostasis is linked to multiple diseases, including Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease, Multiple Sclerosis (MS), and tumorigenesis. This cell line has been validated for surface expression of TFRC by flow cytometry and can be used in various applications, such as transferrin endocytosis studies and binding assays.
