MCF7-Hippo Pathway/TEAD-Luciferase-Reporter Cell Line
| Catalog Number |
CBCL-0684 |
| Price |
Online Inquiry |
| Unit Quantity |
2 x 10^6 cells / 1.0 ml |
Introduction
The MCF7-Hippo Pathway/TEAD-Luciferase-Reporter Cell Line contains the firefly luciferase gene under the control of TEAD responsive elements stably integrated into the human breast cancer cell line, MCF7. Inside the cells, basal unphosphorylated YAP/TAZ remains in the nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter by the activators of the Hippo pathway.
Application
Drug screening and biological assays
Background
TEAD (TEA Domain Transcription Factor) family members are transcription factors that play important roles in cell proliferation, differentiation, and tissue development. They interact with other co - factors to regulate gene expression in various biological processes.
Product Information
| Category |
Cell Signaling Cell Lines |
| Cell Line Name |
MCF7-Hippo Pathway/TEAD-Luciferase-Reporter Cell Line |
| Protein Family |
TEA domain family |
| Gene |
TEAD |
| Species |
Human |
| Host Cell Line |
MCF7 |
| Cell Type |
Human breast cancer |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
MEM medium + 10% FBS |
| Freeze Medium |
90% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
