Catalog Number | CBCL-423 |
Price | Online Inquiry |
Unit Quantity | 1x106 cells / 1.0 ml |
Stable Raji cell line expressing exogenous human PVR gene
Drug screening and biological assays
The poliovirus receptor PVR, also known as CD155 or NECL-5. PVR mediates natural killer cell adhesion and triggers its effector function, participates in mediating tumor cell infiltration and migration, and is the attachment receptor of poliovirus. PVR expression was associated with an unfavorable prognosis insolid tumors such as colon cancer, breast cancer, lung adenocarcinoma, pancreatic cancer, melanoma, and glioblastoma. Raji-OS8 stable cell was used as an artificial antigen presenting cells (APCs), OS8 could function as a membrane anchored T cell engager that directly activates TCR in T cell-based assay.
Category | Immune Molecules Cell Lines |
Cell Line Name | OS8 Human PVR Stable Raji Cell Line |
Pharmaceutical Target | Immune Molecules |
Species | Human |
Host Cell Line | Raji |
Cell Type | Human Burkitt's lymphoma cells |
Morphology | Mostly round |
Growth Properties | Suspension |
Selection Marker | Hygromycin B |
Seeding Density | Thaw entire contents into an appropriate T25 flask. |
Subculture Ratio | Recommended a ratio of 1:3. |
Doubling Time | Approximately 24-36 hours |
Recommended Medium | RPMI1640 + 10% FBS + 400 μg/ml Hygromycin B |
Storage Method | Frozen in liquid nitrogen with 70% medium, 20% FBS and 10% DMSO |
Stability | Stable in culture over 10 passages |
QC | WB |
Shipping | Shipping in dry ice |
Biosafety Level | BSL-1 |
Caution | For Research Use Only |