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OS8 Human PVR Stable Raji Cell Line

Catalog Number CBCL-423
Price Online Inquiry
Unit Quantity 1x106 cells / 1.0 ml

Introduction

Stable Raji cell line expressing exogenous human PVR gene

Application

Drug screening and biological assays

Background

The poliovirus receptor PVR, also known as CD155 or NECL-5. PVR mediates natural killer cell adhesion and triggers its effector function, participates in mediating tumor cell infiltration and migration, and is the attachment receptor of poliovirus. PVR expression was associated with an unfavorable prognosis insolid tumors such as colon cancer, breast cancer, lung adenocarcinoma, pancreatic cancer, melanoma, and glioblastoma. Raji-OS8 stable cell was used as an artificial antigen presenting cells (APCs), OS8 could function as a membrane anchored T cell engager that directly activates TCR in T cell-based assay.

Product Information

Category Immune Molecules Cell Lines
Cell Line Name OS8 Human PVR Stable Raji Cell Line
Pharmaceutical Target Immune Molecules
Species Human
Host Cell Line Raji
Cell Type Human Burkitt's lymphoma cells
Morphology Mostly round
Growth Properties Suspension
Selection Marker Hygromycin B
Seeding Density Thaw entire contents into an appropriate T25 flask.
Subculture Ratio Recommended a ratio of 1:3.
Doubling Time Approximately 24-36 hours
Recommended Medium RPMI1640 + 10% FBS + 400 μg/ml Hygromycin B
Storage Method Frozen in liquid nitrogen with 70% medium, 20% FBS and 10% DMSO
Stability Stable in culture over 10 passages
QC WB
Shipping Shipping in dry ice
Biosafety Level BSL-1
Caution For Research Use Only
For research use only. Not for any other purpose.
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