Background
The poliovirus receptor PVR, also known as CD155 or NECL-5. PVR mediates natural killer cell adhesion and triggers its effector function, participates in mediating tumor cell infiltration and migration, and is the attachment receptor of poliovirus. PVR expression was associated with an unfavorable prognosis insolid tumors such as colon cancer, breast cancer, lung adenocarcinoma, pancreatic cancer, melanoma, and glioblastoma.
Raji-OS8 stable cell was used as an artificial antigen presenting cells (APCs), OS8 could function as a membrane anchored T cell engager that directly activates TCR in T cell-based assay.
