Kinases belong to the family of phosphotransferases and play critical roles in the process known as phosphorylation
in which a phosphorylated substrate and ADP are produced. Kinases are associated with many complex cellular pathways
including cell metabolism, cell signaling, cell transport etc., which makes them very important to human physiology.
Because of their important cellular functions, kinases have become important drug targets in drug discovery and
development for the treatment of human diseases especially diverse cancers.
Catalog Number: CBCL-228
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. The overactivation due to mutation can lead to continuous cell ......
Catalog Number: CBCL-258
Species: Human
Unit Quantity: 1x106 cells / 1.0 ml
ERBB2, also named HER2, is a cell-surface receptor tyrosine kinase, encoding a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. ERBB2 overexpression or ......
Catalog Number: CBCL-199
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
EGFR, the Epidermal growth factor receptor, is a cell-surface receptor tyrosine kinase. EGFR overexpression or overactivity have associated witha number of cancers, including the lung cancer and ......
Catalog Number: CBCL-143
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
EGFR, the Epidermal growth factor receptor, is a cell-surface receptor tyrosine kinase. EGFR overexpression or overactivity have associated witha number of cancers, including the lung cancer and ......
Catalog Number: CBCL-59
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
BRAF is a gene found on chromosome seven that encodes a protein also called BRAF. This protein plays a role in cell growth by sending signals inside the cell promoting, among other functions, cell ......
Catalog Number: CBCL-24
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
The NRAS proto-oncogene is a member of the Ras gene family, NRAS protein can bind GDP/GTP and possess intrinsic GTPase activity. The NRAS gene provides instructions for making a protein called N-Ras ......
Catalog Number: CBCL-77
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
FGFR4 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR4 regulates tumor subtype differentiation in luminal breast cancer and ......
Catalog Number: CBCL-91
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
CD94 & NKG2A, also known as KLRD1 & CD159A. The CD94/NKG2A complex interacts with HLA-E on target cells and inhibit the cytotoxic activity of NK cells to prevent cell lysis.
Ba/F3, a murine ......
Catalog Number: CBCL-238
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other ......
Catalog Number: CBCL-97
Species: Mouse
Unit Quantity: 1x106 cells / 1.0 ml
Bruton's tyrosine kinase (abbreviated BTK) is a tyrosine kinase, which plays a key role in B cell development and maturation.
Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly ......
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