Ba/F3-ETV6-BTK-C481S-Luc2-Stable Cell Line
| Catalog Number | CBCL-0305 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
This stable Ba/F3 cell line expresses an exogenous ETV6-BTK fusion gene with a C481S mutation and luciferase, facilitating studies of BTK signaling and activity.
Application
Drug screening and biological assays
Background
BTK C481S is a mutation in the Bruton's tyrosine kinase (BTK) gene that confers resistance to certain BTK inhibitors used in the treatment of B cell malignancies, by altering the drug-binding site.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | Ba/F3-ETV6-BTK-C481S-Luc2-Stable Cell Line |
| Protein Family | Bruton’s tyrosine kinase family |
| Gene | BTK C481S |
| NCBI Gene ID | 695 |
| Species | Human |
| Host Cell Line | Ba/F3 |
| Cell Type | Murine pro-B cell line |
| Morphology | Lymphoblastoid |
| Growth Properties | Suspension |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.