Ba/F3-ETV6-BTK-C481S-Luc2-Stable Cell Line
| Catalog Number |
CBCL-0305 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
This stable Ba/F3 cell line expresses an exogenous ETV6-BTK fusion gene with a C481S mutation and luciferase, facilitating studies of BTK signaling and activity.
Application
Drug screening and biological assays
Background
BTK C481S is a mutation in the Bruton's tyrosine kinase (BTK) gene that confers resistance to certain BTK inhibitors used in the treatment of B cell malignancies, by altering the drug-binding site.
Product Information
| Category |
Luciferase Reporter Cell Lines |
| Cell Line Name |
Ba/F3-ETV6-BTK-C481S-Luc2-Stable Cell Line |
| Protein Family |
Bruton’s tyrosine kinase family |
| Gene |
BTK C481S |
| NCBI Gene ID |
695 |
| Species |
Human |
| Host Cell Line |
Ba/F3 |
| Cell Type |
Murine pro-B cell line |
| Morphology |
Lymphoblastoid |
| Growth Properties |
Suspension |
| Selection Marker |
Hygromycin B |
| Recommended Medium |
RPMI1640+10%FBS+1000µg/mL Hygromycin B |
| Freeze Medium |
70% RPMI1640+20% FBS+10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
