Healthy, radiant skin is fundamentally dependent on optimal hydration and a competent skin barrier. The stratum corneum, the outermost layer of the skin, acts as the primary barrier against transepidermal water loss (TEWL) and environmental aggressors. Its unique "brick and mortar" structure, comprising corneocytes (bricks) and intercellular lipids (mortar), is essential for retaining moisture.
The most effective cosmetic products will do the three:
- Humectancy: Absorbing and Binding water from the dermis and the surrounding atmosphere.
- Occlusion: Sealing moisture into the skin.
- Barrier repair: Delivery of lipids/moisturizing factors that resemble the natural barrier lipids.
Our comprehensive Moisturization and Hydration Preclinical Solutions evaluate your cosmetic formulas to demonstrate their effectiveness and deliver quantitative evidence for your marketing claims before you proceed to costly clinical studies. We give you the confidence to understand how and how well your product moisturizes your skin immediately and for the long term at a cellular and tissue level.
Workflow
In Vitro Models
We offer a range of in vitro and ex vivo models to mimic the structure and physiology of human skin:
- Reconstructed Human Epidermis (RHE)
- Full-Thickness Skin Model
- Human Keratinocyte or Fibroblast Monolayer Cultures
- Excised Human or Porcine Skin
Key Test Parameters
- Transepidermal Water Loss (TEWL)
- Stratum Corneum Hydration
- Natural Moisturizing Factor (NMF) Content
- Epidermal Lipid Analysis
- Aquaporin (AQP) Expression
- Histological Evaluation
Partner with us to accelerate your product development with robust, non-animal-tested efficacy data, ensuring your claims are backed by solid science.
- Skin Whitening Efficacy Test
- Skin Irritation Test
- Hazardous and Restricted Substance Test
- Skin Microbiota
- Hair Growth, Alopecia & Canities
- Eye Irritation Test
- Skin Anti-Ageing Test
- Skin Sensitization Test
- In Vitro Skin Absorption Test
- Skin Corrosion Test