Neurotoxicity Service - Creative Bioarray

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Neurotoxicity is the direct or indirect adverse modification of the structure and/or function of the nervous system by a chemical compound. Candidate drug molecules can act directly on neural cells, or interfere with key metabolic pathways, leading to neurological impairment. They can affect neurotransmission and neural communication, neural development, or the mature nervous system and lead to adverse neurological outcomes. Furthermore, delayed effects may also occur after initial neurotoxicant exposure. In order to predict the potential for delayed neurotoxicity, in vitro assessment can be used at early stages to screen the possible risk before expensive in vivo or clinical tests.

Creative Bioarray's In Vitro Neurotoxicity Service provides comprehensive, high-throughput screening solutions to evaluate drug-induced neurotoxicity, helping pharmaceutical and biotech companies make informed decisions in preclinical development.

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Service Offerings

Available in vitro models:

Primary neuronal cultures (rodent or human-derived)
Induced pluripotent stem cell (iPSC)-derived neurons and glial cells
Neuroblastoma cell lines
3D neurospheres & brain organoids
Co-culture systems (neurons + astrocytes/microglia)

Detection types and methods:

Cell viability and cytotoxicity assays (MTT, LDH release, ATP quantification)
Neurite outgrowth and morphology analysis (high-content imaging)
Electrophysiological and functional readouts (MEA recordings, calcium flux assays)
Oxidative stress and mitochondrial function assessments
Neuroinflammation markers (cytokine release, glial activation assays)
High-throughput imaging and phenotypic profiling
Genotoxicity & biomarker profiling (qPCR, RNA-seq, proteomics)

Key Features

Comprehensive model portfolio: From simple neuronal cell lines to advanced human iPSC-derived systems.

Customizable study design: Flexible assay combinations tailored to specific compound classes and mechanisms.

Expert data interpretation: In-depth analysis and reporting to support decision-making in preclinical programs.

Fast turnaround: Efficient workflows to accelerate project timelines without compromising quality.

FAQ

At which stage of development should in vitro neurotoxicity studies be performed?

Typically, in vitro neurotoxicity studies are performed during the preclinical safety evaluation process in order to identify potential hazards prior to moving to in vivo studies and/or clinical trials.

Can the panel be customized to test for specific mechanisms of neurotoxicity?

Yes, custom assay panels can be developed to assess endpoints related to mitochondrial dysfunction, excitotoxicity, neuroinflammation, or other aspects depending on the characteristics of your compound(s).

What type of compounds can be evaluated using this service?

Small molecules, biologics, gene therapies and environmental toxins can all be evaluated for their neurotoxic potential using our assays.

How do you ensure that your models are relevant to human physiology?

We use human iPSC-derived neurons as well as advanced 3D models to more closely recapitulate in vivo neuronal environments.

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