Ligand Binding Assays - Creative Bioarray

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Ligand binding assays (LBAs) are a widely used method in drug discovery and development for determining the interaction between a ligand (drug candidate) and a macromolecule (protein, receptor, or enzyme). By measuring this interaction, LBAs provide valuable information about a compound's potency, selectivity, and mechanism of action. Quantifying the binding affinity allows researchers to evaluate how effectively a drug candidate binds to its intended target, which is crucial in early drug screening and lead optimization.

Applications of Ligand Binding Assays

Biomarker Quantification: Measure biomarkers in biological matrices for disease diagnosis and monitoring.
PK/PD Studies: Analyze pharmacokinetics and pharmacodynamics of therapeutic candidates.
Antibody Characterization: Evaluate antibody-antigen binding affinity and specificity.
Receptor-Ligand Studies: Explore drug-target interactions and mechanisms of action.
Biologics Development: Support biosimilar characterization and comparability studies.

Our Service Offering

Our Ligand Binding Assay service covers the entire workflow process starting from early method development through to preclinical sample analysis. Our services are designed to deliver reliable, reproducible and regulatory compliant data that support timely decisions throughout drug development.

Custom method development and optimization
Assay qualification and validation
Preclinical and clinical sample analysis
Immunogenicity and biomarker testing
Regulatory-compliant data reporting

Our LBA Capabilities

We utilize state-of-the-art automation, sensitive detection systems, and rigorous validation procedures to ensure reproducibility. Our team has extensive experience in developing custom assays tailored to the specific properties of novel biologics and complex modalities.

ELISA
Automated ELISA systems
Meso Scale Discovery (MSD)
Luminex
Fluorescence immunoassay (FIA)
Flow Cytometry

Why Choose Us

Expertise: A dedicated scientific team with extensive experience in LBAs for diverse molecule types.

Flexibility: Tailored assay design and validation strategies to meet unique client needs.

Quality & Compliance: Adherence to international regulatory guidelines.

Cutting-Edge Technology: Access to the latest immunoassay platforms and automation systems.

Integrated Support: Seamless service from early discovery through clinical development.

By leveraging our advanced ligand binding assay capabilities, we help transform your drug development challenges into regulatory-ready solutions, ensuring data integrity and accelerating the path to market.

FAQ

What types of molecules can be analyzed using your LBAs?

We support:

Large molecules: Antibodies, proteins, peptides, ADCs, bispecifics

Small molecules: Compounds <1 kDa (with hybrid LBA-LC/MS approaches when needed)

Complex matrices: Serum, plasma, tissue homogenates, CSF

Can assays be customized for unique client needs?

Absolutely. We design and optimize assays tailored to the characteristics of your molecule and study requirements.

What types of information do LBAs provide?

LBAs can provide critical information about the binding characteristics of your compounds. For example, we can measure the binding affinity (Kd) which provides information about the strength of the binding interaction between a ligand and its target. We can also measure binding kinetics (kon and koff), which describe the on- and off-rates of the binding event. This information can help you to prioritize the most promising drug candidates.

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