Ba/F3-LMNA-NTRK1-G595R-Luc2-Stable Cell Line
| Catalog Number |
CBCL-0316 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
This stable Ba/F3 cell line expresses exogenous LMNA-NTRK1 protein with a G595R mutation and a luciferase mutation in the NTRK1 part, facilitating studies of NTRK1 signaling and activity.
Application
Drug screening and biological assays
Background
NTRK1 G595R is a point mutation in the NTRK1 gene, which encodes the TrkA neurotrophin receptor. This mutation can lead to constitutive activation of the receptor and is associated with certain cancers and developmental disorders.
Product Information
| Category |
Luciferase Reporter Cell Lines |
| Cell Line Name |
Ba/F3-LMNA-NTRK1-G595R-Luc2-Stable Cell Line |
| Protein Family |
Neurotrophic tyrosine receptor kinase family |
| Gene |
NTRK1 G595R |
| NCBI Gene ID |
4914 |
| Species |
Human |
| Host Cell Line |
Ba/F3 |
| Cell Type |
Murine pro-B cell line |
| Morphology |
Lymphoblastoid |
| Growth Properties |
Suspension |
| Selection Marker |
Puromycin, Hygromycin B |
| Recommended Medium |
RPMI1640+10%FBS+1mg/mL Hygromycin B |
| Freeze Medium |
70% RPMI1640+20% FBS+10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
