CHO-Human BTLA-Stable Cell Line
| Catalog Number |
CBCL-0573 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The CHO-Human BTLA-Stable Cell Line is engineered to express the receptor full-length human BTLA (Uniprot: Q7Z6A9-1), used to mimic cancer target cells. When co-cultured with human HVEM Reporter Cell, the BTLA/HVEM interaction drives NF-kB-mediated luminescence. Blocking the BTLA/HVEM interaction by either anti-BTLA or anti-HVEM antibodies results in a decrease in luminescence.
Application
Useful for cell-based BTLA binding assay
Background
BTLA (B and T Lymphocyte Attenuator) is an inhibitory receptor expressed on T cells, B cells, and NK cells. It binds to HVEM (TNFRSF14) and delivers inhibitory signals that suppress lymphocyte activation, promoting immune tolerance.
Product Information
| Category |
Immune Checkpoint Cell Lines |
| Cell Line Name |
CHO-Human BTLA-Stable Cell Line |
| Protein Family |
B and T lymphocyte attenuator family |
| Gene |
BTLA |
| Species |
Hamster |
| Host Cell Line |
CHO |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Puromycin (2 μg/mL) |
| Recommended Medium |
F-12K + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
