CHO-Human CD64-Low Expression-Stable Cell Line
| Catalog Number |
CBCL-0005 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
A CHO cell line has been developed to stably express the full - length human CD64 (Uniprot: P12314-1) receptor. This cell line has different levels of CD64 expression (High, Medium, Low), which can be used to test whether an agonist antibody can enhance its agonistic activity in a CD64 - dependent manner.
Application
Useful for cell-based CD64 binding assay
Background
FCGR1A encodes a high-affinity receptor for the Fc region of IgG. It is expressed on monocytes, macrophages, and dendritic cells. This receptor has a high binding affinity for monomeric IgG, allowing it to efficiently capture and internalize immune complexes. It is involved in the initiation of immune responses, the activation of immune cells, and the regulation of inflammation. It also plays a role in antibody-mediated phagocytosis and the clearance of apoptotic cells.
Product Information
| Category |
Fc Receptor Cell Lines |
| Cell Line Name |
CHO-Human CD64-Low Expression-Stable Cell Line |
| Protein Family |
Fc gamma receptor |
| Gene |
CD64/FCGR1A |
| NCBI Gene ID |
2209 |
| Species |
Hamster |
| Host Cell Line |
CHO |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Hygromycin B (20 μg/mL) |
| Recommended Medium |
F-12K+ 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
