CHO-Human PD-L1-High Expression-Stable Cell Line

Introduction

The CHO-Human PD-L1-High Expression-Stable Cell Line is engineered to express the receptor full-length human PD-L1 (Uniprot: Q9NZQ7-1), with different levels of PD-L1 expression (High, Medium, Low), which can be used to mimic cancer target cells with various PD-L1 expression levels. When co-cultured with Human 4-1BB HEK293 Reporter Cell and anti-human 4-1BB/PD-L1 BsAb, the anti-human 4-1BB/PD-L1 BsAb can be crosslinked, thereby strengthening 4-1BB pathway-activated luminescence.

Application

Useful for cell-based PD-L1 binding assay

Background

PDL1 (Programmed Death-Ligand 1) is an immune checkpoint protein that is expressed on the surface of tumor cells and some immune cells. It binds to its receptor PD-1 on T-cells, inhibiting T-cell activation and promoting immune tolerance, which helps tumors evade immune surveillance.

Product Information