Introduction
Recombinant CHO-K1 cells have been created to stably overexpress human adrenoceptor alpha 1B (ADRA1B) on their surface. These cells contain high levels of the G protein Gαq, which is essential for coupling with the receptor in downstream signaling pathways.
Background
The ADRA1B gene encodes the alpha - 1B adrenergic receptor, a G protein-coupled receptor. It is expressed in various smooth muscle tissues, such as blood vessels, the gastrointestinal tract, and the uterus. Activation of ADRA1B receptors causes smooth muscle contraction, leading to vasoconstriction, increased gastrointestinal motility, and uterine contraction. It is involved in regulating blood flow, digestive function, and reproductive - related processes. Dysregulation of ADRA1B receptor function may contribute to cardiovascular and gastrointestinal disorders.
