CHO-K1-ADRA1D-Stable Cell Line
| Catalog Number |
CBCL-0065 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
Recombinant CHO-K1 cells have been developed to stably overexpress human adrenoceptor alpha 1D (ADRA1D) on their surface. These cells contain high levels of the G protein Gαq, which is crucial for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
The ADRA1D gene encodes the alpha - 1D adrenergic receptor, a G protein-coupled receptor. It is found in smooth muscle tissues of the blood vessels, prostate, and other organs. Activation of ADRA1D receptors results in smooth muscle contraction, contributing to vasoconstriction and prostate smooth muscle tone. It plays a role in regulating blood pressure and prostate function. ADRA1D receptor - targeted drugs are being investigated for the treatment of hypertension and prostate - related diseases.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
CHO-K1-ADRA1D-Stable Cell Line |
| Protein Family |
Adrenoceptors |
| Gene |
ADRA1D |
| NCBI Gene ID |
149 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 400 μg/ml Geneticin |
| Freeze Medium |
45% culture medium + 45% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
