CHO-K1-ADRA2C/Gα15-Stable Cell Line
| Catalog Number |
CBCL-0068 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
Recombinant CHO-K1 cells have been developed to stably overexpress human adrenoceptor alpha 2C (ADRA2C) on their surface. These cells contain high levels of the G protein Gαi, which is essential for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
The ADRA2C gene encodes the alpha - 2C adrenergic receptor, a G protein-coupled receptor. It is mainly expressed in the central nervous system, particularly in areas involved in the regulation of mood, anxiety, and stress responses. Activation of ADRA2C receptors inhibits neurotransmitter release and affects neuronal signaling pathways. It plays a role in modulating emotional and behavioral responses to stress. Dysregulation of ADRA2C receptor function may be associated with psychiatric disorders such as depression and anxiety.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
CHO-K1-ADRA2C/Gα15-Stable Cell Line |
| Protein Family |
Adrenoceptors |
| Gene |
ADRA2C |
| NCBI Gene ID |
152 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 400 μg/ml Geneticin, 100 μg/ml Hygromycin B |
| Freeze Medium |
45% culture medium + 45% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
