CHO-K1-BB1-Stable Cell Line

Introduction

Recombinant CHO-K1 cells have been created to stably overexpress human bombesin receptor 1 (BB1) on their surface. These cells contain high levels of the G protein Gαq, which is crucial for coupling with the receptor in downstream signaling pathways.

Application

Drug screening and biological assays

Background

The BB1 gene encodes a receptor that is part of the bombesin receptor family. Bombesin - like peptides bind to this receptor, and activation of the BB1 receptor is involved in various physiological processes such as regulation of smooth muscle contraction, gastrointestinal motility, and secretion. It also plays a role in the central nervous system, influencing functions like satiety, anxiety, and stress responses.

Product Information