CHO-K1-CB2-Stable Cell Line
| Catalog Number |
CBCL-0081 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
A CHO-K1 cell line has been developed to stably overexpress human cannabinoid receptor 2 (CB2) on its surface. This cell line contains high levels of the G protein Gαi, which is essential for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
The CNR2 gene encodes the cannabinoid receptor type 2 (CB2), a G protein-coupled receptor. It is mainly expressed in immune cells such as lymphocytes, macrophages and dendritic cells, as well as in some peripheral tissues like the spleen and tonsils. Activation of the CB2 receptor has anti-inflammatory and immunomodulatory effects. It can regulate cytokine production, immune cell activation and migration, and plays a role in immune responses and inflammatory diseases.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
CHO-K1-CB2-Stable Cell Line |
| Protein Family |
Cannabinoid receptor |
| Gene |
CNR2/CB2 |
| NCBI Gene ID |
1269 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 400 μg/ml Geneticin |
| Freeze Medium |
45% culture medium + 45% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
