CHO-K1-CTLA4-Stable Cell Line
| Catalog Number | CBCL-0529 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
The CHO-K1-CTLA4-Stable Cell Line consists of recombinant CHO-K1 cells that stably overexpress human cytotoxic T-lymphocyte associated protein 4 (CTLA4) on their surface. The surface expression of CTLA4 is confirmed by FACS analysis.
Application
Drug screening and biological assays
Background
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is a key immune checkpoint receptor expressed on activated T cells. It binds to B7 molecules (CD80/CD86) on antigen-presenting cells with higher affinity than CD28, delivering an inhibitory signal that suppresses T cell activation and prevents autoimmune responses. Mutations in CTLA-4 are associated with autoimmune diseases such as type 1 diabetes and autoimmune lymphoproliferative syndrome.
Product Information
| Category | Immune Checkpoint Cell Lines |
| Cell Line Name | CHO-K1-CTLA4-Stable Cell Line |
| Protein Family | Cytotoxic T-lymphocyte-associated protein 4 family |
| Gene | CTLA4 |
| NCBI Gene ID | 1493 |
| Species | Hamster |
| Host Cell Line | CHOK1 |
| Cell Type | Chinese hamster ovary cell line |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.