Introduction
A CHO-K1 cell line has been developed to stably overexpress human C-X-C motif chemokine receptor 3 (CXCR3) on its surface. This cell line contains high levels of the G protein Gαi, which is crucial for coupling with the receptor in downstream signaling pathways.
Background
The CXCR3 gene, also known as CD183, encodes a chemokine receptor that is expressed on activated T lymphocytes, natural killer cells, and some other immune cells. It binds to chemokines such as CXCL9, CXCL10, and CXCL11. Activation of CXCR3 by these chemokines regulates immune cell migration, recruitment to inflammatory sites, and activation, playing important roles in the immune response against viral infections, tumor immunity, and autoimmune diseases.
