CHO-K1-CXCR5/Gα15-Stable Cell Line
| Catalog Number | CBCL-0088 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
A CHO-K1 cell line has been created to stably overexpress human C-X-C motif chemokine receptor 5 (CXCR5) on its surface. This cell line contains high levels of the G protein Gαi, which is essential for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
The CXCR5 gene, also known as CD185, encodes a chemokine receptor that is mainly expressed on B lymphocytes and some follicular helper T cells. It binds to the chemokine CXCL13. Activation of CXCR5 by CXCL13 regulates B cell migration to lymphoid follicles, where B cells undergo maturation, antibody class - switching, and affinity maturation. CXCR5 plays a crucial role in the formation of germinal centers and the humoral immune response.
Product Information
| Category | GPCR Cell Lines |
| Cell Line Name | CHO-K1-CXCR5/Gα15-Stable Cell Line |
| Protein Family | Chemokine receptor |
| Gene | CXCR5/CD185 |
| NCBI Gene ID | 643 |
| Species | Hamster |
| Host Cell Line | CHOK1 |
| Cell Type | Chinese hamster ovary cell line |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.