CHO-K1-cyno 4-1BB-Stable Cell Line

Catalog Number	CBCL-0559
Price	Online Inquiry
Unit Quantity	1 x 10^6 cells / 1.0 ml

Introduction

The CHO-K1-cyno 4-1BB-Stable Cell Line consists of recombinant CHO-K1 cells that stably overexpress cynomolgus TNF receptor superfamily member 9 (4-1BB) on their surface.

Application

Drug screening and biological assays

Background

4-1BB (TNFRSF9, CD137) is a co-stimulatory receptor expressed on activated T cells, NK cells, and dendritic cells. It binds to 4-1BB Ligand (TNFSF9) on APCs, promoting T cell proliferation, survival, and cytokine production. 4-1BB agonists are being tested in cancer immunotherapy.

Product Information

Category	Immune Checkpoint Cell Lines
Cell Line Name	CHO-K1-cyno 4-1BB-Stable Cell Line
Protein Family	TNF receptor superfamily
Gene	4-1BB
NCBI Gene ID	3604
Species	Hamster
Host Cell Line	CHOK1
Cell Type	Chinese hamster ovary cell line
Morphology	Epithelial
Growth Properties	Adherent
Recommended Medium	F12K, 10% FBS, 8 μg/ml Puromycin
Freeze Medium	95% complete growth medium + 5% DMSO
Storage Method	Frozen in liquid nitrogen.
Stability	Validated for at least 10 passages
Mycoplasma	Negative
Sterility Testing	Negative
Shipping	Shipping in dry ice
Biosafety Level	BSL-1
Caution	For Research Use Only

For research use only. Not for any other purpose.