CHO-K1-DP1/Gα15-Stable Cell Line
| Catalog Number |
CBCL-0158 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
The CHO-K1-DP1/Gα15-Stable Cell Line is designed to stably express the DP1 (prostaglandin D receptor 1) and the Gα15 protein.
Application
Drug screening and biological assays
Background
PTGDR, also known as the prostaglandin D receptor or DP1, is a G-protein coupled receptor that binds prostaglandin D2 (PGD2). PGD2 is involved in regulating sleep, inflammation, and immune responses. Activation of PTGDR by PGD2 leads to increased cAMP production and various cellular responses, including vasodilation and inhibition of platelet aggregation. PTGDR is a potential target for drugs used to treat allergic rhinitis and other inflammatory diseases.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
CHO-K1-DP1/Gα15-Stable Cell Line |
| Protein Family |
Prostanoid receptor |
| Gene |
PTGDR/DP1 |
| NCBI Gene ID |
5729 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B |
| Freeze Medium |
45% culture medium + 45% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
